Visualisation of time-varying respiratory system elastance in experimental ARDS animal models

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Visualisation of time-varying respiratory system elastance in experimental ARDS animal models

BACKGROUND Patients with acute respiratory distress syndrome (ARDS) risk lung collapse, severely altering the breath-to-breath respiratory mechanics. Model-based estimation of respiratory mechanics characterising patient-specific condition and response to treatment may be used to guide mechanical ventilation (MV). This study presents a model-based approach to monitor time-varying patient-ventil...

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Visualisation of Time-Variant Respiratory System Elastance in ARDS Models.

Model-based mechanical ventilation (MV) can be used to characterise patient-specific condition and response to MV. This paper presents a novel method to visualise respiratory mechanics during MV of patients suffering from acute respiratory distress syndrome. The single compartment lung model is extended to monitor time-varying respiratory system elastance within each breathing cycle. Monitoring...

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Time-Varying Respiratory Elastance for Spontaneously Breathing Patients

Respiratory mechanics models can be used to optimise patient-specific mechanical ventilation (MV), but are limited to fully sedated MV patients who are not spontaneously breathing. This research presents a non-invasive model-based method to determine respiratory mechanics of spontaneously breathing MV patients. Patient-specific respiratory mechanics of 22 spontaneously breathing patients are de...

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Time-Varying Elastance Model

Background Contractile function of the ex vivo, isolated left atrium (LA) has been described by a time-varying elastance, but this atrial chamber property has not been shown in vivo. Methods and Results Instantaneous LA pressure-volume (P-V) relations were studied in 12 anesthetized, autonomically blocked, atrially paced dogs. LA volume was calculated from orthogonal sonomicrometer pairs using ...

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Time-Varying Respiratory System Elastance: A Physiological Model for Patients Who Are Spontaneously Breathing

BACKGROUND Respiratory mechanics models can aid in optimising patient-specific mechanical ventilation (MV), but the applications are limited to fully sedated MV patients who have little or no spontaneously breathing efforts. This research presents a time-varying elastance (E(drs)) model that can be used in spontaneously breathing patients to determine their respiratory mechanics. METHODS A ti...

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ژورنال

عنوان ژورنال: BMC Pulmonary Medicine

سال: 2014

ISSN: 1471-2466

DOI: 10.1186/1471-2466-14-33